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Articles (47)
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Heparin-binding EGF-like growth factor: a juxtacrine growth factor

Ryo Iwamoto, Eisuke Mekada

Journal:

Cytokine & Growth Factor Reviews

Année:

2000

Langue:

english

Fichier:

PDF, 400 KB

english, 2000

Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination

Tetsushi Kagawa, Eisuke Mekada, Yuji Shishido, Kazuhiro Ikenaka

Journal:

Journal of Neuroscience Research

Année:

1997

Langue:

english

Fichier:

PDF, 1.46 MB

english, 1997

Loss of motility-related protein 1 (MRP1/CD9) and integrin α3 expression in endometrial cancers

Shingo Miyamoto, Akiko Maruyama, Kaoru Okugawa, Kohei Akazawa, Hideo Baba, Yoshihiko Maehara, Eisuke Mekada

Journal:

Cancer

Année:

2001

Langue:

english

Fichier:

PDF, 234 KB

english, 2001

Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer

Kenzo Sonoda, Shingo Miyamoto, Ayano Yamazaki, Hiroaki Kobayashi, Manabu Nakashima, Eisuke Mekada, Norio Wake

Journal:

Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 776 KB

english, 2007

HB-EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development

Seigo Minami, Ryo Iwamoto, Eisuke Mekada

Journal:

Developmental Dynamics

Année:

2008

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2008

Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer

Hiroshi Yagi, Fusanori Yotsumoto, Kenzo Sonoda, Masahide Kuroki, Eisuke Mekada, Shingo Miyamoto

Journal:

International Journal of Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 828 KB

english, 2009

Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis

Jingo Kusukawa, Fuminori Ryu, Tadamitsu Kameyama, Eisuke Mekada

Journal:

Journal of Oral Pathology & Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 233 KB

english, 2001

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy

Shingo Miyamoto, Hiroshi Yagi, Fusanori Yotsumoto, Tatsuhiko Kawarabayashi, Eisuke Mekada

Journal:

Cancer Science

Année:

2006

Langue:

english

Fichier:

PDF, 335 KB

english, 2006

Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells

Naohiko Koshikawa, Hiroto Mizushima, Tomoko Minegishi, Fuyuki Eguchi, Fusanori Yotsumoto, Kazuki Nabeshima, Shingo Miyamoto, Eisuke Mekada, Motoharu Seiki

Journal:

Cancer Science

Année:

2011

Langue:

english

Fichier:

PDF, 611 KB

english, 2011

10.1038/90795

Saito, Michiko, Iwawaki, Takao, Taya, Choji, Yonekawa, Hiromichi, Noda, Munehiro, Inui, Yoshiaki, Mekada, Eisuke, Kimata, Yukio, Tsuru, Akio, Kohno, Kenji

Journal:

Nature Biotechnology

Année:

2001

Langue:

english

Fichier:

PDF, 2.78 MB

english, 2001

c-myc activates RCC1 gene expression through E-box elements

Tsuneoka, Makoto, Nakano, Fumie, Ohgusu, Hideko, Mekada, Eisuke

Journal:

Oncogene

Année:

1997

Langue:

english

Fichier:

PDF, 827 KB

english, 1997

Ras/MEK signaling suppresses Myc-dependent apoptosis in cells transformed by c-myc and activated ras

Tsuneoka, Makoto, Mekada, Eisuke

Journal:

Oncogene

Année:

2000

Langue:

english

Fichier:

PDF, 568 KB

english, 2000

Possible involvement of CD81 in acrosome reaction of sperm in mice

Maya Tanigawa, Kiyoko Miyamoto, Satoshi Kobayashi, Masahiro Sato, Hidenori Akutsu, Masaru Okabe, Eisuke Mekada, Keiichi Sakakibara, Mami Miyado, Akihiro Umezawa, Kenji Miyado

Journal:

Molecular Reproduction and Development

Année:

2008

Langue:

english

Fichier:

PDF, 233 KB

english, 2008

Characterization of diphtheria-toxin-resistant mutants lacking receptor function or containing nonribosylatable elongation factor 2

Kenji Kohno, Tsuyoshi Uchida, Eisuke Mekada, Yoshio Okada

Journal:

Somatic Cell and Molecular Genetics

Année:

1985

Langue:

english

Fichier:

PDF, 1007 KB

english, 1985

MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans

Hitomi Masuda, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Takashi Hirose, Hiroki Moribe, Eisuke Mekada, Masato Okada

Journal:

FEBS Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2012

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer

Kaoru Nishikawa, Tomohiro Asai, Hirokazu Shigematsu, Kosuke Shimizu, Hisakazu Kato, Yoshihiro Asano, Seiji Takashima, Eisuke Mekada, Naoto Oku, Tetsuo Minamino

Journal:

Journal of Controlled Release

Année:

2012

Langue:

english

Fichier:

PDF, 546 KB

english, 2012

Extension of Juxtamembrane Domain of Diphtheria Toxin Receptor Arrests Translocation of Diphtheria Toxin Fragment A into Cytosol

Tsuyoshi Takahashi, Toshiyuki Umata, Eisuke Mekada

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 182 KB

english, 2001

Identification of Serum Factor Inducing Ectodomain Shedding of proHB-EGF and Studies of Noncleavable Mutants of proHB-EGF

Michinari Hirata, Toshiyuki Umata, Tsuyoshi Takahashi, Masaaki Ohnuma, Yoshiki Miura, Ryo Iwamoto, Eisuke Mekada

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 274 KB

english, 2001

CD9 Amino Acids Critical for Upregulation of Diphtheria Toxin Binding

Hidetoshi Hasuwa, Yuji Shishido, Ayano Yamazaki, Terukazu Kobayashi, Xiaochun Yu, Eisuke Mekada

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 267 KB

english, 2001

Methylamine facilitates demonstration of specific uptake of diphtheria toxin by CHO cell and toxin-resistant CHO cell mutants

Eisuke Mekada, Kenji Kohno, Masahiro Ishiura, Tsuyoshi Uchida, Yoshio Okada

Journal:

Biochemical and Biophysical Research Communications

Année:

1982

Langue:

english

Fichier:

PDF, 408 KB

english, 1982

Monoclonal antibodies against diphtheria toxin fragment A: Characterization and introduction into living cells

Tamotsu Yoshimori, Masaaki Yamada, Hideo Sugawa, Eisuke Mekada, Tsuyoshi Uchida, Yoshio Okada

Journal:

Experimental Cell Research

Année:

1984

Langue:

english

Fichier:

PDF, 654 KB

english, 1984

Mutant with diphtheria toxin receptor and acidification function but defective in entry of toxin

Kenji Kohno, Helene Hayes, Eisuke Mekada, Tsuyoshi Uchida

Journal:

Experimental Cell Research

Année:

1987

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1987

Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation

Daisuke Nanba, Yumi Kinugasa, Chie Morimoto, Michiko Koizumi, Hisako Yamamura, Katsuhito Takahashi, Nobuyuki Takakura, Eisuke Mekada, Koji Hashimoto, Shigeki Higashiyama

Journal:

Biochemical and Biophysical Research Communications

Année:

2006

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2006

Validation of HB-EGF and amphiregulin as targets for human cancer therapy

Fusanori Yotsumoto, Hiroshi Yagi, Satoshi O. Suzuki, Eiji Oki, Hiroshi Tsujioka, Touru Hachisuga, Kenzo Sonoda, Tatsuhiko Kawarabayashi, Eisuke Mekada, Shingo Miyamoto

Journal:

Biochemical and Biophysical Research Communications

Année:

2008

Langue:

english

Fichier:

PDF, 200 KB

english, 2008

S5-4 Cardiac hypertrophy is inhibited by antagonism of metalloproteinase processing of HB-EGF

Seiji Takashima, Masanori Asakura, Masafumi Kitakaze, Yoshihiro Asano, Yasunori Shintani, Shigeki Higashiyama, Eisuke Mekada, Masatsugu Hori

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2002

Langue:

english

Fichier:

PDF, 192 KB

english, 2002

Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer

Takuji Fujita, Shingo Miyamoto, Ichiro Onoyama, Kenzo Sonoda, Eisuke Mekada, Hitoo Nakano

Journal:

Cancer Letters

Année:

2003

Langue:

english

Fichier:

PDF, 184 KB

english, 2003

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice

Takayo Takemura, Yuichi Yoshida, Shinichi Kiso, Yukiko Saji, Hisao Ezaki, Mina Hamano, Takashi Kizu, Mayumi Egawa, Norihiro Chatani, Kunimaro Furuta, Yoshihiro Kamada, Ryo Iwamoto, Eisuke Mekada, Shig

Journal:

Hepatology Research

Année:

2012

Langue:

english

Fichier:

PDF, 764 KB

english, 2012

Improved methods using HVJ(Sendai virus) for introducing substances into cells

Tsuyoshi Uchida, Yasuko Miyake, Masaru Yamaizumi, Eisuke Mekada, Yoshio Okada

Journal:

Biochemical and Biophysical Research Communications

Année:

1979

Langue:

english

Fichier:

PDF, 492 KB

english, 1979

Modification of the cell surface with neuraminidase increases the sensitivities of cells to diphtheria toxin and Pseudomonas aeruginosa exotoxin

Eisuke Mekada, Tsuyoshi Uchida, Yoshio Okada

Journal:

Experimental Cell Research

Année:

1979

Langue:

english

Fichier:

PDF, 723 KB

english, 1979

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

Yamaizumi, Masaru, Mekada, Eisuke, Uchida, Tsuyoshi, Okada, Yoshio

Journal:

Cell

Année:

1978

Langue:

english

Fichier:

PDF, 443 KB

english, 1978

Antibodies introduced into living cells by red cell ghosts are functionally stable in the cytoplasm of the cells

Yamaizumi, Masaru, Uchida, Tsuyoshi, Mekada, Eisuke, Okada, Yoshio

Journal:

Cell

Année:

1979

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1979

Entry of Diphtheria Toxin into Cells: Possible Existence of Cellular Factor(s) for Entry of Diphtheria Toxin into Cells Was Studied in Somatic Cell Hybrids and Hybrid Toxins

Yasufumi Kaneda, Tsuyoshi Uchida, Eisuke Mekada, Mahito Nakanishi and Yoshio Okada

Journal:

The Journal of Cell Biology

Année:

1984

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1984

The Membrane Protein CD9/DRAP 27 Potentiates the Juxtacrine Growth Factor Activity of the Membrane-Anchored Heparin-Binding EGF-Like Growth Factor

Shigeki Higashiyama, Ryo Iwamoto, Katsutoshi Goishi, Gerhard Raab, Naoyuki Taniguchi, Michael Klagsbrun and Eisuke Mekada

Journal:

The Journal of Cell Biology

Année:

1995

Langue:

english

Fichier:

PDF, 749 KB

english, 1995

Membrane-Anchored Heparin-Binding EGF-Like Growth Factor (HB-EGF) and Diphtheria Toxin Receptor-Associated Protein (DRAP27)/CD9 Form a Complex with Integrin α3β1 at Cell-Cell Contact Sites

Kuniaki Nakamura, Ryo Iwamoto and Eisuke Mekada

Journal:

The Journal of Cell Biology

Année:

1995

Langue:

english

Fichier:

PDF, 4.35 MB

english, 1995

The 27-kD Diphtheria Toxin Receptor-Associated Protein (DRAP27) from Vero Cells Is the Monkey Homologue of Human CD9 Antigen: Expression of DRAP27 Elevates the Number of Diphtheria Toxin Receptors on Toxin-Sensitive Cells

Toshihide Mitamura, Ryo Iwamoto, Toshiyuki Umata, Tetsuya Yomo, Itaru Urabe, Makoto Tsuneoka and Eisuke Mekada

Journal:

The Journal of Cell Biology

Année:

1992

Langue:

english

Fichier:

PDF, 1.58 MB

english, 1992

Co-occurrence of tetraspanin and ROS generators

Moribe, Hiroki, Mekada, Eisuke

Journal:

Worm

Année:

2013

Langue:

english

Fichier:

PDF, 147 KB

english, 2013

Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegans

Moribe, Hiroki, Konakawa, Ryouji, Koga, Daisuke, Ushiki, Tatsuo, Nakamura, Kuniaki, Mekada, Eisuke, Chisholm, Andrew D.

Journal:

PLoS Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 4.94 MB

english, 2012

Elevated Levels of Anti‐CD9 Antibodies in the Cerebrospinal Fluid of Patients with Subacute Sclerosing Panencephalitis

Shimizu, Toko, Matsuishi, Toyojiro, Iwamoto, Ryo, Handa, Kazuyo, Yoshioka, Hiroshi, Kato, Hirohisa, Ueda, Shigeharu, Hara, Hideo, Tabira, Takeshi, Mekada, Eisuke

Journal:

The Journal of Infectious Diseases

Année:

2002

Langue:

english

Fichier:

PDF, 279 KB

english, 2002

Enhanced CD9 Expression in the Mouse and Human Brains Infected with Transmissible Spongiform Encephalopathies

Doh-Ura, Katsumi, Mekada, Eisuke, Ogomori, Koji, Iwaki, Toru

Journal:

Journal of Neuropathology and Experimental Neurology

Année:

2000

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2000

Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers

Iwamoto, Ryo, Takagi, Mika, Akatsuka, Jun-ichi, Ono, Ken-ichiro, Kishi, Yoshiro, Mekada, Eisuke

Journal:

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

Année:

2016

Langue:

english

Fichier:

PDF, 924 KB

english, 2016

Identification of Diphtheria Toxin Receptor and a Nonproteinous Diphtheria Toxin-Binding Molecule in Vero Cell Membrane

Eisuke Mekada, Yoshio Okada and Tsuyoshi Uchida

Journal:

The Journal of Cell Biology

Année:

1988

Langue:

english

Fichier:

PDF, 682 KB

english, 1988

Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis

Murata, Takuya, Mekada, Eisuke, Hoffman, Robert M.

Journal:

Cell Cycle

Année:

2017

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2017

ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis

Iwamoto, Ryo, Mine, Naoki, Mizushima, Hiroto, Mekada, Eisuke

Journal:

Journal of Cell Science

Année:

2017

Langue:

english

Fichier:

PDF, 3.41 MB

english, 2017

10.5360/membrane.5.281

Mekada, Eisuke

Année:

1980

Fichier:

PDF, 1.87 MB

1980

10.1271/kagakutoseibutsu1962.39.644

MEKADA, Eisuke

Journal:

KAGAKU TO SEIBUTSU

Année:

2001

Fichier:

PDF, 1.25 MB

2001

ErbB and HB-EGF Signaling in Heart Development and Function

Iwamoto, Ryo, Mekada, Eisuke

Journal:

Cell Structure and Function

Année:

2006

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2006

Diphtheria toxin receptor.

MEKADA, Eisuke

Journal:

Nippon Saikingaku Zasshi

Année:

1993

Fichier:

PDF, 944 KB

1993